Pharmacological action Veramyst Nasal Spray
SCS. Anti-inflammatory, antiallergic, antipruritic effect in intranasal, inhaled, applied topically. At therapeutic doses, has practically no effect on the hypothalamic-pituitary-adrenal axis.
Pharmacokinetics Veramyst Nasal Spray
When intranasal administration at doses up to 1 mg of fluticasone plasma concentrations are very low and close to the threshold of sensitivity of the method (0.05 ng / ml).
When applied topically exposed to virtually no systemic absorption.
After oral administration of 87-100% is excreted through the intestine, with up to 75% – in the form of nevsosavshegosya unchanged substance, with a dose of 6 mg of 64% is excreted unchanged.
After i / v administration elimination is characterized by high plasma clearance.
T1 / 2 at 3 hours
Statement Veramyst Nasal Spray
For inhalation: a basic anti-inflammatory therapy of asthma, chronic obstructive pulmonary disease (including chronic bronchitis and emphysema).
For intranasal use: prevention and treatment of allergic rhinitis.
For external use: eczema (including atopic, children, discoid), nodular prurigo, psoriasis (excluding widespread plaque) neyrodermatozy, lichen planus, contact dermatitis, discoid lupus erythematosus, generalized erythroderma (as an additional tool) insect bites, Red sudamen, seborrheic dermatitis.
Dosage and administration Veramyst Nasal Spray
Individual depends on the dosage form employed and the patient’s age.
Side effect Veramyst Nasal Spray
With inhalation use: possibly the development of oral candidiasis and throat, hoarseness, paradoxical bronchospasm, with prolonged use at high doses, concomitant or previous use of oral corticosteroids in rare cases, there loss of function of the adrenal cortex, osteoporosis, growth retardation in children, cataracts , glaucoma.
When intranasal application: very rarely – nasal dryness and irritation, unpleasant taste and odor, and in rare cases – nasal septum perforation, especially during surgery in the nasal cavity in history.
For exterior use: possible burning and itching at the application, with prolonged use may be atrophic changes of the skin – thinning, striae, increased superficial blood vessels, hypertrichosis, hypopigmentation, allergic contact dermatitis and secondary infection, especially when using occlusive dressings, and when applied to the area folds of skin with prolonged use at high doses can be systemic absorption of the drug with the development of symptomatic hypercortisolism (more common in infants, as nappy can function as an occlusive dressing).
Contraindications Veramyst Nasal Spray
For nasal and inhalation hypersensitivity to fluticasone.
For external use: acne rosacea, acne vulgaris, perioral dermatitis, primary viral infection of the skin (herpes simplex, varicella), perianal and genital itching, the primary lesions of bacterial and fungal etiology, children under 6 months (for fluticasone in the form of a cream) , children under 1 year (for fluticasone in the form of ointments), hypersensitivity to fluticasone.
Pregnancy and breast feeding Veramyst Nasal Spray
Safety of fluticasone during pregnancy is not currently installed.
Pregnancy and lactation is possible in cases where the intended benefits to the mother outweighs the potential risk to the fetus or child.
It is believed that the penetration of fluticasone passes into breast milk is unlikely.
Cautions Veramyst Nasal Spray
When intranasal application: with careful use after systemic administration of glucocorticoids.
Fluticasone for inhalation is not intended for relief of bronchial asthma attacks. Used with caution with concomitant pulmonary tuberculosis, as well as simultaneously with inhibitors of isoenzyme CYP3A4. Translation of a patient with oral corticosteroids for inhaled fluticasone should be used with caution under the control of adrenocortical function. Fluticasone treatment should be terminated gradually. Should regularly monitor the dynamics of growth of children receiving inhaled corticosteroids for a long time.
For external use: Avoid contact with eyes, systemic absorption is most likely to have babies.
Regardless of the method of introducing long-term use may inhibition of adrenocortical function.
Effects on ability to drive and control mechanisms
Effect of fluticasone on ability to drive and use machines is unlikely.
